NSAIDs work on a chemical level. They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in making prostaglandins. By blocking the Cox ...

All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition ... NSAID inhibition of COX in vitroare the source of the enzyme, the Michaelis constant (K m)of the endogenous ...

COX-1 protects the stomach lining and regulates blood platelets, while COX-2 is primarily associated with inflammation and ...

"Ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) work by inhibiting cyclooxygenase enzymes, COX-1 and COX-2, which are used by the body to make signaling molecules called ...

1), which between them commanded sales in excess ... and the number of chemical abstracts dealing with potential inhibitors of the COX enzyme rose markedly, with more than 2,500 per year recorded ...

The enzyme Cox-2 (cyclooxygenase-2), released at sites of inflammation, stimulates the production of prostaglandin E 2, which promotes a region of localized hypersensitivity surrounding the injury.

The first-in-human study, which imaged the COX-2 enzyme, offers a never-before-seen view of inflammation in the brain, opening the door for COX-2 PET imaging to be used in clinical and research ...

A novel PET imaging method, using the radiotracer 11C-MC1, successfully quantifies COX-2 enzyme levels in the human brain. This technique opens the door for earlier detection, monitoring of disease ...

The first-in-human study, which imaged the COX-2 enzyme, offers a never-before-seen view of inflammation in the brain, opening the door for COX-2 PET imaging to be used in clinical and research ...

This effect is modified by a genetic variation in cyclo-oxygenase-2 (COX-2), a key enzyme in fatty acid metabolism and inflammation, Fradet et al. report. Previous research has shown that omega-3 ...

Table 1. Example of the range of IC 50 ... Important considerations when investigating NSAID inhibition of COX in vitroare the source of the enzyme, the Michaelis constant (K m)of the endogenous ...