Purpose: A summary of the basic science underlying the current controversies regarding cyclooxygenase-2 (COX-2)-selective nonsteroidal antiinflammatory drugs (NSAIDs), including data on their ...

Meloxicam is an enolcarboxamide with preferential COX-2 activity. Studies conducted on ... or those receiving concomitant administration of other drugs, including digoxin, furosemide, warfarin ...

to pharmacologically modulate COX-2 function in pathological situations without disrupting its normal function. Microsomal PGES should also be assessed as a specific drug target that may have only ...

Ferroptosis plays an essential role in chronic liver diseases, and cyclooxygenase-2 (COX-2) affects liver fibrosis through multiple mechanisms. + ...

The league table listing the 'top 20' drugs includes rofecoxib (Vioxx) and celecoxib (Celebrex), two inhibitors of the prostaglandin-forming cyclooxygenase (COX) (Fig. 1), which between them ...

Most NSAIDs block both Cox-1 and Cox-2 enzymes. They include the over-the-counter drugs: Aspirin has some benefits that other NSAIDs do not. The biggest is that aspirin works against the formation ...