For example, nimesulide is a weak competitive inhibitor of COX-1 but a potent time-dependent inhibitor of COX-2, whereas celecoxib exhibits slow competitive binding and, at higher concentrations ...

A drug developer's dream, rationally designed to quell inflammation, COX-2 inhibitors are also prime candidates for preventing cancer or its recurrence. Gary J. Kelloff, chief of the chemoprevention ...

This culminated in the introduction of a new class of anti-inflammatories — the COX2 selective inhibitors — with improved tolerance. There may be other forms of COX that could account for some ...

This simplistic division of the roles of COX-1 and COX-2 drove the search for 'selective' COX-2 inhibitors and further ... Table 1. Example of the range of IC 50 values (µM) generated for ...