Meloxicam is an enolcarboxamide with preferential COX-2 inhibitory activity. In vitro studies with human tissues have confirmed the high affinity of meloxicam for COX-2, whereas COX-1 was ...

One possibility is that COX-2 interacts with different substrates to generate different products 10, which in turn activate different receptors 11. The effects of COX-2 may also depend on its ...

A drug developer's dream, rationally designed to quell inflammation, COX-2 inhibitors are also prime candidates for preventing cancer or its recurrence. Gary J. Kelloff, chief of the chemoprevention ...

A novel PET imaging method, using the radiotracer 11C-MC1, successfully quantifies COX-2 enzyme levels in the human brain. This technique opens the door for earlier detection, monitoring of disease ...

This effect is modified by a genetic variation in cyclo-oxygenase-2 (COX-2), a key enzyme in fatty acid metabolism and inflammation, Fradet et al. report. Previous research has shown that omega-3 ...

Meloxicam is an enolcarboxamide with preferential COX-2 activity. Studies conducted on experimental models and human tissues indicate that meloxicam is a more potent inhibitor of COX-2 than COX-1 ...