These inhibitors are typically small molecules designed by considering the structure of the active site or the substrate specificity of the enzyme. A common problem with small inhibitors ...

We had at our disposal not only an enzyme assay but also ... by studying the three-dimensional structure of a specially designed thiol-containing inhibitor with the metalloprotease thermolysin ...

catalysis and inhibition of cancer target mitochondrial creatine kinase by a covalent inhibitor, Structure (2025). DOI: ...

Influencing their activity can control their rates of reaction. Different chemicals can influence enzyme activity. Inhibitors can be used to stop an enzyme from binding to its substrate.

Get Instant Summarized Text (Gist) New inhibitors of the enzyme human 15-lipoxygenase-2 (h15-LOX-2) have been identified using computational tools and virtual screening. This enzyme is involved in ...