Inhibiting the entire receptor complex prevents IL-6 signal transduction to inflammatory ... Conclusion: Tocilizumab, a novel IL-6R inhibitor, may be beneficial for the treatment of RA in patients ...

Bristol–Myers Squibb (BMS) has entered a potential ∼US$1 billion agreement with Alder Biopharmaceuticals involving Alder's lead drug ALD518, a humanized monoclonal antibody specific for ...

UK-based EUSA Pharma has begun a late-stage trial of its antibody siltuximab in COVID-19, hoping that the IL-6 inhibitor will succeed where class rivals from Roche and Sanofi/Regeneron have failed.

Five patients started the IL-6 inhibitor tocilizumab (Actemra). In the group initiating conventional DMARDs, 71% were on steroids alone and most of the rest were on methotrexate with steroids.

"Similar trends" that fell short of statistical significance were also seen when JAK inhibitors were compared with less popular types of biologic therapy, such as interleukin (IL)-6 inhibitors ...