The works, which are linked to the new Symmetry Park industrial development, mean the A41 Oxford Road will be closed from the M40 Junction 9 roundabout to the Bicester park and ride roundabout.
Drivers in and around Buckinghamshire will have 48 National Highways road closures to watch out for this week.
A404, from 9pm December 9 to 5am December 10, slight delays (under 10 minutes): M40 northbound, junction 3 to junction 4 lane closures, carriageway closure and diversion route for maintenance work ...