Mitochondrial deoxyribonucleic acid (mtDNA ... alongside a decrease in 7S DNA levels and strand-asynchronous replication intermediates. These findings suggest that TEFM is crucial for the proper ...

Alexeyev and his collaborators aim to overcome what he calls an interspecies barrier of mitochondrial DNA replication. “That ...

Damage to the genetic material of mitochondria—the mitochondrial DNA or mtDNA for short—can lead to diseases such as ...

DePamphilis points out that 40 human diseases are caused by mutations in genes required for DNA replication or repair, another 7 are caused by mutations generated during mitochondrial DNA ...

Mitochondrial deoxyribonucleic acid ... alongside a decrease in 7S DNA levels and strand-asynchronous replication ...

Researchers at the University of Gothenburg have identified a small molecule, PZL-A, that restores function in the defective ...

Damage to the mitochondria, the “power plants” of the cells, contributes to many diseases. Researchers from Heinrich Heine University Düsseldorf (HHU) and the University of Cologne led by HHU ...

measured the mitochondrial levels of free deoxynucleotide triphosphates (dNTPs), the building blocks of new DNA strands made during DNA replication, in tissues from young and old rats. As shown in ...

The POLG gene regulates the production of DNA polymerase gamma, an enzyme that copies mitochondrial DNA. Without it, the ...

A medical breakthrough could result in the first treatment for rare but serious diseases in which genetic defects disrupt cellular energy production. Researchers have identified a molecule that helps ...

Mitochondrial diseases, arising from mutations in mitochondrial DNA (mtDNA), are a diverse group of disorders that lead to ...