The structural basis for imatinib resistance in chronic myeloid leukaemia (CML) involves the emergence of imatinib-resistant BCR-ABL point mutations; mutations are usually those that impair drug ...

The disadvantage of a competitive inhibitor is that higher concentrations of the substrate can nullify its effect. Non-competitive inhibitors could be more effective as they cannot be overwhelmed ...

All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive ...