TL1A signaling is believed to amplify inflammation and drives fibrosis associated with asthma and inflammatory bowel disease (IBD); thus, targeting TL1A with TEV-’574 may mitigate the over ...

TL1A is encoded by TNFSF15 and is produced by endothelial cells. 5 Expression of TL1A can be induced in endothelial cells and chondrocytes under the influence of the inflammatory cytokines TNF and ...

According to AbbVie, FG-M701 could offer best-in-class functional characteristics compared to what it calls first-generation TL1A antibodies, with the potential to offer “greater efficacy and ...

Armed with positive data from a phase 2b trial, Teva and Sanofi have decided to push their anti-TL1A antibody duvakitug into a phase 3 programme in inflammatory bowel disease (IBD). The results of ...

SL-325 is a potential first-in-class Death Receptor 3 (DR3) blocking antibody designed to achieve a complete and durable blockade of the clinically validated DR3/TL1A pathway. Shattuck’s ...

The company said it is keeping an eye on TNF-like ligand 1A (TL1A) therapies to be used in ... placebo effect at certain trial sites, with a signal seen when looking beyond these sites – however ...

HXN-1002 targets α4β7 and TL1A with the aim of treating ulcerative colitis and Crohn's disease, while HXN-1003 targets TL1A and IL23 in order to treat colitis and skin inflammation. Should the ...

MAdCAM-1, mucosal addressin cell adhesion molecule 1; STAT, signal transducer and activator of transcription; T cell, T lymphocytes; TL1A, tumour-necrosis factor-like cytokine 1A; α4β7 ...

We believe SPY003 has the potential to be a best-in-class IL-23 antibody and a compelling combination partner with our α4β7 and TL1A antibodies ... in inhibiting pSTAT signaling and IL-17 ...

It also signed a license agreement with China’s FutureGen to develop a next-generation anti-TL1A antibody for IBD. Its successful immunology drug Rinvoq is approved for treating both UC and CD ...

In head-to-head preclinical studies, SPY003 demonstrated equivalent potency to risankizumab in inhibiting pSTAT signaling and IL ... our anti-α4β7 and anti-TL1A antibodies that can be delivered ...