Buffalo Bills' head coach Sean McDermott provided injury updates on CB, LB and safety on Wednesday in Orchard Park.

The hamstring issue comes at a horrible time for the Bills and Milano, who has played excellent football in the past two playoff games. He made several important plays against the Ravens, including a pass breakup on Lamar Jackson’s two-point conversion attempt in the third quarter of Buffalo’s 27-25 victory.

ORCHARD PARK - A season-long trend, one in which the Buffalo Bills had been given a reprieve from in the last few weeks, has returned at quite an inopportune time: Injuries on the defensive side of the ball.

In the most anticipated game of the 2024-2025 NFL season, the Baltimore Ravens and Buffalo Bills are set for a crash course collision on Sunday night.

Bills head coach Sean McDermott said Wednesday that Milano (hamstring) was a limited participant at practice, Maddy Glab of the Bills' official site reports. Milano played a season-high 88 percent of defensive snaps during last Sunday's divisional-round win over the Ravens,

Defensive tackle DaRon Payne (knee/finger) also didn't practice along with linebacker Bobby Wagner (ankle). Tight end Zach Ertz (ribs) had a rest day, along with pass rusher Dante Fowler Jr. (non injury related).

Von Miller was a menace against his former team. Buffalo had limited Miller’s snaps all season long, but he saw an uptick in snaps on Wild Card Weekend. Miller created five pressures on just 16 pass-rush snaps (20 total) in the win earning him an 81.2 pass rush grade. Buffalo needs this from Miller throughout the entirety of the playoffs.

Buffalo Bills safety Taylor Rapp and offensive tackle Dion Dawkins (illness) were both non-participants in the team's walkthrough on Wednesday while linebacker Matt Milano (biceps/hamstring) was limited.

The Buffalo Bills defense is healthy and it showed on ... Von Miller turned back the clock against his former team and Matt Milano played his best game since returning to the unit from injury.

Buffalo Bills linebacker Matt Milano (biceps, hamstring) was a limited participant at Wednesday's team practice. The eighth-year pro spent the early portion of the season dealing with a bicep injury,

Milano is dealing with hamstring soreness, which kept him out of the final few defensive plays in their victory over the Baltimore Ravens. He made his season debut on Dec. 1 and after shaking off the rust, has been one of the Bills' better performers through two playoff games.