CME activities, cases, challenges, videos, and more teaching and learning tools from the New England Journal of Medicine.

Obinutuzumab, a humanized type II anti-CD20 monoclonal antibody, provided significantly better renal responses than placebo in a phase 2 trial involving patients with lupus nephritis receiving ...

THE relation between the thyroid gland and rheumatic disorders has long excited interest. 1–7 In particular, an association between some of the connective-tissue diseases and Hashimoto's ...

LYSOZYME, a bacteriolytic enzyme discovered in 1922 by Sir Alexander Fleming, 2 is found in a number of biologic fluids. The enzyme is a basic protein of low molecular weight that lyses ...

Familial HLH is a success story in modern medicine. Initially a disease that was largely unknown and fatal, it is now understood on a molecular level and is curable. Moreover, HLH is an archetype ...

Whether the large effect size of endovascular thrombectomy (EVT) for stroke due to large-vessel occlusion applies to stroke due to medium-vessel occlusion is unclear. In a multicenter, prospective ...

Endovascular treatment (EVT) of stroke with large-vessel occlusion is known to be safe and effective. The effect of EVT for occlusion of medium or distal vessels is unclear. We randomly assigned ...

Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case ...

A total of 867 patients underwent randomization: 291 were assigned to receive acalabrutinib–venetoclax, 286 acalabrutinib–venetoclax–obinutuzumab, and 290 chemoimmunotherapy (of whom 143 ...

In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and ...

The patients studied on the medical wards of the Boston City Hospital had been admitted primarily for treatment of severe liver disease or the complications of alcoholism. One patient was admitted ...

It is well recognized that, in many cases, endometrial carcinoma is a well differentiated tumor bearing a marked resemblance to the parent organ tissue. Elton 14 noted in such tumors appearing ...