Dec 23, 2024 · Cocaine hydrochloride has a characteristic saline, slightly bitter taste. Cocaine hydrochloride is very soluble in water and freely soluble in alcohol. Stability. Cocaine hydrochloride crystals and powder should be stored in well-closed, light-resistant containers; topical solutions of the drug should be stored at 15–30°C.

Cocaine (C 17 H 21 NO 4) is a powerfully addictive, psychoactive, stimulant drug. On the street it is usually sold as a fine, white crystal powder. The powdered, hydrochloride salt form can be snorted or dissolved in water and injected. Use in any form is illegal in the U.S. when used as recreational drug.

Mar 7, 2024 · As reported in the literature, cocaine hydrochloride causes an increase in observed blood pressure and heart rate. In the Phase 3 clinical study with COCAINE HYDROCHLORIDE nasal solution, increases in blood pressure and heart rate were observed for 60 minutes or longer following pledget removal.

Nov 5, 2024 · Cocaine hydrochloride nasal solution is used to numb the mucous membrane inside the nose before a medical procedure or surgery. This medicine is a local anesthetic. This medicine is to be given only by or under the direct supervision of your doctor.

Nov 11, 2024 · The pharmacokinetics of GOPRELTO (cocaine hydrochloride) nasal solution have been assessed in 74 healthy adult subjects across 4 studies. Following intranasal application of two 40 mg pledgets applied to each nasal cavity (160 mg cocaine hydrochloride total dose) for 20 minutes, the geometric mean (SD) cocaine C max was 43.2

Cocaine can cause psychological dependence (a strong desire to continue using the medicine because of the "high" feeling it produces). This may lead to cocaine abuse (more frequent use and/or use of larger amounts of cocaine) and to an increased chance of serious side effects. Cocaine abuse has caused death from heart or breathing failure.

Jun 26, 2024 · NUMBRINO TM (cocaine hydrochloride) nasal solution is a clear, blue-green, aqueous solution, available in 4% strength. Each 1 mL contains cocaine hydrochloride 40 mg, equivalent to 35.7 mg of cocaine free base; 4% as 160 mg/4 mL or 400 mg/10 mL.

Sep 2, 2024 · Hydrochloride is the most commonly used salt, and 15.5% of all drugs contain it. All types of oxycodone are the hydrochloride salt, but sometimes drug data information will just shorten the name to oxycodone. But oxycodone hydrochloride and …

Nov 6, 2024 · The recommended dose of GOPRELTO is two soaked cottonoid pledgets placed in each nasal cavity, equivalent to 40 mg cocaine hydrochloride per pledget, for a total dose of 160 mg for four pledgets. The total dose for any one procedure or surgery should not exceed 160 mg, or 3 mg/kg, cocaine hydrochloride.

Jan 29, 2020 · Generic name: cocaine hydrochloride Dosage form: Nasal Solution Company: Lannett Company, Inc. Treatment for: Nasal Anesthesia. Numbrino (cocaine hydrochloride) nasal solution is a local anesthetic indicated for the introduction of local anesthesia of the mucous membranes for diagnostic procedures and surgeries on or through the nasal cavities ...